BEYOND THE BELT; DOES WEIGHT REDUCTION STABILIZE KIDNEY FUNCTION IN CHRONIC KIDNEY DISEASE?
Formerly Published in Vol. 8 No. 2 Jan. - Jun., 2023
DOI:
https://doi.org/10.83120/pmj.vol3no2.25Keywords:
obesity, chronic kidney disease, weight reduction, diabetic nephropathyAbstract
Background: Obesity is an established risk factor for chronic kidney disease (CKD). Several mechanisms have been found out linking obesity to CKD and these include diabetes mellitus, hypertension, metabolic syndrome, hyperfiltration and inflammation. Obesity may lead to CKD or the worsening of existing CKD. Interventions leading to weight loss in obese patients have been shown to improve renal function and reduce proteinuria. This case illustrates stabilization of renal function in an obese patients with CKD following weight loss.
Aim: Our aim is to remind physicians of the role of conservative management of CKD by weight reduction in improving outcomes of management of CKD.
Index case: The index patient is a 40 year old man with type 2 diabetes mellitus and hypertension who was referred to the nephrology clinic for management of CKD. He was found to have a body mass index of 40.5kg/m2 and waist:hip ratio of 1.2. He embarked on other measures in conservative management of CKD without much success. With introduction of weight loss program and reduction of body mass index from 40.5kg/m2 to 29.1mg/kg2, there was a stabilization in renal function.
Conclusion: Weight loss led to stabilization of renal function and reduction of proteinuria resulting in good outcome of conservative management of CKD in the patient
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References
1. Kidney Early Evaluation Program. Am J Kidney Dis. Mar 2005;45(2 Suppl 2):S1-135.
2. Hall JE, Henegar JR, Dwyer TM, et al. Is obesity a major cause of chronic kidney disease? Adv Ren Replace Ther. 2004;11:41-54.
3. Hall JE, Jones DW, Kuo JJ, da Silva A, Tallam LS, Liu J. Impact of the obesity epidemic on hypertension and renal disease. Curr Hypertens Rep. 2003;5:386-392.
4. Kopple JD, Feroze U. The effect of obesity on chronic kidney disease. J Ren Nutr. 2011;21:66-71.
5. Kato S, Nazneen A, Nakashima Y, et al. Pathological influence of obesity on renal structural changes in chronic kidney disease. Clin Exp Nephrol. 2009;13:332-340.
6. Satirapoj B, Supasyndh O, Mayteedol N, et al. Obesity and its relation to chronic kidney disease: A population-based, cross-sectional study of a Thai army population and relatives. Nephrology. 2013;18:229-234.
7. Garrison RJ, Kannel WB, Stokes J, 3rd, Castelli WP. Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev Med. 1987;16:235-251.
8. Willett WC, Manson JE, Stampfer MJ, et al. Weight, weight change, and coronary heart disease in women. Risk within the 'normal' weight range. JAMA. 1995;273:461-465.
9. Agnani S, Vachharajani VT, Gupta R, Atray NK, Vachharajani TJ. Does treating obesity stabilize chronic kidney disease? BMC Nephrol. 2005;6:7.
10. Saxena AK. Emerging global epidemic of obesity: the renal perspective. Ann Saudi Med. 2006;26:288-295.
11. Wiggins KJ, Johnson DW. The influence of obesity on the development and survival outcomes of chronic kidney disease. Adv Chronic Kidney Dis. 2005;12:49-55.
12. Oluyombo R, Ayodele OE, Akinwusi PO, et al. A community study of the prevalence, risk factors and pattern of chronic kidney disease in osun state, South west Nigeria. West Afr J Med. 2013;32:85-92.
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